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25‐Hydroxyvitamin D and Body Mass Index in Female Adolescents
Author(s) -
Gwathmey TanYa M,
Nixon Patricia,
Chappell Mark,
Washburn Lisa
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1093.15
Subject(s) - medicine , body mass index , endocrinology , blood pressure , obesity , percentile , vitamin d and neurology , aldosterone , population , cohort , plasma renin activity , renin–angiotensin system , statistics , mathematics , environmental health
Low 25‐hydroxyvitamin D (Vit D) is an endocrine derangement associated with adult obesity and may result in hypertension and target organ damage through dis‐inhibition of renin synthesis. As obesity among US adolescents is most prevalent in the female population (NHANES 2008), this study compared Vit D status, body mass index (BMI) and blood pressure (BP) in 14 year old male and female adolescents. BMI percentiles (BMIz), adjusted for sex and age, were greater in females than males (0.9±0.2, N=23 vs. 0.4±0.1, N=21; p=0.01), while serum Vit D levels were lower in females (15±1 ng/ml) than in males (21±3 ng/ml; p=0.03). BP percentiles (BPP) were determined according to sex, age, and height, and did not differ between groups for systolic (19.8±2.6 vs. 20.7±2.8) or diastolic (33.0±3.9 vs. 30.2±3.2) BPP. Despite lower Vit D levels in females, both plasma renin activity (2.2±0.3 vs. 3.0±0.5 ng/ml/hr) and serum aldosterone (9.6±1.4 vs. 10.5±1.5 ng/dl) were similar between groups. In summary, female adolescents exhibited higher BMIz and lower Vit D compared to their male peers. Alterations in BP and components of the renin angiotensin aldosterone system typically associated with Vit D deficiency in adults were not evident in this cohort of adolescents. We conclude that higher BMIz may be associated with lower Vit D in female adolescents, serving as a risk factor for the development of cardiovascular disease in adulthood. HD047584