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Autonomic control in a rat model of sepsis induced by cecal ligation and puncture
Author(s) -
Veiga Glaucia Raquel Luciano,
Oyama Lila Missay,
Fazan Rubens,
Pontes Roberto,
Campos Ruy,
Bergamaschi Cassia
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1091.55
Subject(s) - sepsis , medicine , baroreflex , blood pressure , heart rate , ligation , baroreceptor , anesthesia , cardiology , endocrinology
The aim of this study was to evaluate cardiovascular parameters: blood pressure (BP), heart rate (HR) and BP and HR variability, renal sympathetic nerve activity (RSNA) and baroreflex control of HR in animals submitted to the experimental model of sepsis induced by cecal ligation and puncture compared to sham rats. Male Wistar rats were submitted to sepsis (CLP) and studied 24 or 48h later (n=8/group). BP and HR were recorded in conscious rats and spectral analysis in the frequency domain was performed. Baroreflex was evaluated by changes infusion of vasoactive drugs. Although no differences in BP was observed, RSNA was significantly decreased in both sepsis groups compared to Sham (Sham 92.5±6 × Sepsis 24hrs 58.5±6 × Sepsis 48hrs 62.6±9 pps). In both sepsis groups it was observed a significant increased in LF (low frequency) to HR (Sham 15±2 × Sepsis 24hrs 25±4 and Sepsis 48hrs 23±6 mmHg 2 ) and a decrease in HF (high frequency) (Sham 85±2 × Sepsis 24hrs 75±4 × Sepsis 48hrs 77±6 un). The sensitivity of baroreflex gain of HR was increased in Sepsis 24hrs compared to sham (Sepsis 24hrs −4.35±0.45 and Sham −2.03±0.14 bpm/mmHg). Taken altogether the present study suggest that the fall in RSNA in sepsis was accompanied by an increase in LF and baroreceptor sensitivity, such adjustments are apparently independent of BP changes and maybe involved in the sepsis evolution. Supported by: CNPq, FAPESP