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The 2‐nitrate‐1,3‐dibuthoxypropan, a nitric oxide donor, alters autonomic function in spontaneously hypertensive rats
Author(s) -
Silva Maria Socorro França,
Monteiro Matheus M. O.,
Medeiros Isac A.,
Braga Valdir A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1091.52
Subject(s) - bradycardia , hexamethonium , atropine , nitric oxide , chemistry , medicine , endocrinology , blood pressure , anesthesia , heart rate
The 2‐nitrate‐1,3‐dibuthoxypropan (NDBP), an organic nitrate synthesized from glycerin, increases NO levels in rabbit aortic smooth muscle cells and causes a biphasic response: hypotension and bradycardia followed by hypertension and tachycardia in Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. However, its effect on autonomic control has not been investigated. This study evaluated the action of NDBP on autonomic function in SHR and WKY rats. Atropine (2 mg/kg) blunted the bradycardia induced by NDBP (15 mg/kg) in WKY and SHR (−265±25 vs −48±7 bpm, n=6 and −255±9 vs −25±10 bpm, n=6; p<0.05). Furthermore, the pressor response to the compound was potentiated (35±7 vs 65±4 mmHg in WKY; 33±10 vs 82±6 mmHg in SHR; p<0.05). Vagotomy also reduced the bradycardia in both WKY and SHR (−136±8 vs −17±2, n=4 and −171±36 vs −8±2, n=6, p<0.05). Moreover, hexamethonium (30 mg/kg) reduced both bradycardia (−261±10 vs 1±3 in WKY; −282±21 vs −26±25 in SHR, n=4; p<0.05) and pressor response (41±4 vs 0±1‐in WKY; 44±9 vs −12±7 in SHR, n=4; p<0.05) elicited by NDBP. In conclusion, NDBP, in addition to its effects as NO donor, induces cardiovascular effects by altering autonomic function.