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Negative pressure on an occluded limb induces sympathetic activation
Author(s) -
Cui Jian,
Blaha Cheryl,
Herr Michael D.,
Mast Jessica,
Muller Matthew D.,
Drew Rachel C.,
Sinoway Lawrence I.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1091.1
Subject(s) - distension , medicine , blood pressure , heart rate , reflex , baroreflex , anesthesia , anatomy , hemodynamics , cardiology
We have shown that venous distension induced by saline infusion into veins of an arterially occluded arm increases muscle sympathetic nerve activity (MSNA) and blood pressure (BP). However, the effects of vascular distension in lower limbs have not been examined. In this study, we employed airtight pressure tanks to apply 100 mmHg negative pressure on an arterially occluded limb (termed “NPOL”) to induce the tissue deformation without fluid translocation to the limb. We hypothesized that the NPOL would induce MSNA activation when applied to upper as well as lower limbs. BP, heart rate, and MSNA from the non‐treated leg were assessed in 13 young healthy subjects with arm or leg NPOL for 2 min. Limb occlusion without suction was used as a control. The NPOL increased limb circumference (arm: 3.8 ± 0.6; leg: 2.8 ± 0.6 %), MSNA (arm: 7.0 ± 1.3 bursts/min; 183 ± 17 units/min; leg: 7.3 ± 1.1 bursts/min; 172 ± 27 units/min) and BP (arm: 4.4 ± 1.0 mmHg; leg: 10.5 ± 3.4 mmHg). It had no effect on heart rate. Occlusion did not evoke responses. These data indicate that the limb tissue deformation evokes MSNA and BP increases. These observations combined with our previous findings suggest that arm and leg vascular distension evokes a powerful pressor reflex. Supported by AHA 0635245 N, NIH P01 HL096570, M01 RR010732 and UL1 RR033184.