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Activation of hemostatic pathways by exercise induced hyperthermia
Author(s) -
Hopman Maria,
Eijsvogels Thijs,
Veltmeijer Matthijs,
Geffen Mark,
Thijssen Dick,
Heerde Waander
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1084.10
Subject(s) - plasmin , hyperthermia , fibrinolysis , coagulation , thrombin generation , thrombin , medicine , endocrinology , chemistry , platelet , biochemistry , enzyme
BACKGROUND Retrospective studies indicated that patients with heat stroke have a sustained activation of coagulation, fibrinolysis and platelets. However, little is known about changes in haemostatic parameters in hyperthermic athletes without exertional heat stroke. Therefore, the aim of this study was to determine changes in thrombin and plasmin generation after exercise induced hyperthermia. METHODS Core body temperature was measured before and at the finish line of a 15 km run (n=16, 51±8 years). Venous blood samples were collected pre‐ and post‐race. The Novel Haemostasis Assay was used to measure thrombin and plasmin generation simultaneously. This allows insight in the interaction between coagulation and fibrinolysis. RESULTS Core body temperature increased from 37.7±0.5°C to 39.4±0.9°C. The time to thrombin peak decreased from 9.2±2.3 min to 8.1±1.0 min (p<0.05), while the thrombin peakheight increased from 178±63 nM to 190±67 nM (p<0.001). The plasmin peak‐time increased from 28.4±9.5 min to 32.3±10.9 min (p<0.05), with a decrease in plasmin peakheight from 4.3±4.0 nM to 2.7±2.1 nM (p=0.07). CONCLUSION An increase of 1.7°C in core body temperature stimulated coagulation by enhancing thrombin generation and reducing plasmin generation. These innovative results suggest that exercise induced hyperthermia leads to activation of the coagulation pathway.