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30.5±1.5°C Is the Optimal Hypothermia to Protect Hypoxic/Ischemic Heart
Author(s) -
Ning Xue-Han,
Sekhar L N,
Kupchik N L,
Corson M A,
Werrbach J H,
Tylee T S,
Soh YK,
Wang E,
Villet O M,
Ge M,
Fan LP,
Yao L,
Olson A K,
Zhu C,
Anderson D L,
Chen SH,
Portman M A
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1083.2
Subject(s) - hypothermia , medicine , cardiopulmonary bypass , in vivo , anesthesia , cardiology , ischemia , cardiac function curve , biology , heart failure , microbiology and biotechnology
Objective To determine an optimal temperature in hypothermia protection for myocardium. Methods Isolated rabbit hearts infused with Langendorff model; Pig hearts in vivo infused with cardiopulmonary bypass; Patient treated with the cooling protocol at Harborview Med Ctr. The animal hearts were treated with a giving range of temperatures prior to and during cardioplegic ischemia. DP, dP/dtmax, cardiac power (CP), etc were monitored. Results Following reperfusion the off‐pump function of pig hearts returned to baseline (BL) level in the 29–30°C treatment group. In the 34–35°C group the recovery was significantly lower (P<0.05; DP=44.0± 9.4%, dP/dtmax =28.0±5.9%, CP=21.6±10.3% of BL). The 32.5°C treatment showed some recovery (P<0.05). The isolated rabbit hearts showed similar results to the pig hearts in vivo. One of the authors (XH Ning) suffered from a sudden cardiac arrest for more than 6 minutes in 2009. He was treated with Hypothermic Rescue (32°C central catheter) and had a remarkable recovery. Conclusion 30.5±1.5°C is an optimal temperature in hypothermia protection. (Partial support from NIH HL‐60666 and CHRMC HR‐5836).