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Exercise preconditioning prevents skeletal muscle wasting in monocrotaline‐induced cardiac cachexia
Author(s) -
Gonçalves Daniel,
Henriques-Coelho Tiago,
Ferreira Rita,
Fonseca Hélder,
Neuparth Maria João,
Justino Joana,
Duarte Daniela,
Vieira Sara,
Amado Francisco,
Duarte José Alberto,
Leite-Moreira Adelino
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1078.31
Subject(s) - wasting , cachexia , medicine , endocrinology , anabolism , protein kinase b , inflammation , skeletal muscle , heart failure , weight loss , catabolism , gastrocnemius muscle , muscle atrophy , apoptosis , chemistry , metabolism , obesity , biochemistry , cancer
Cardiac cachexia is characterized by an imbalance between anabolic and catabolic factors that lead to weight loss. The present study addresses the preventive effect of exercise training on muscle wasting in an animal model of right ventricular failure induced by monocrotaline (MCT) administration. After 4 weeks of training or cage living, male Wistar rats were injected with MCT (60mg/kg) (ExMCT and SedMCT, respectively) or saline (ExC and SedC, respectively), and sacrificed after an additional 4week‐period of movement confined to cage's space. Gastrocnemius and blood samples were collected for biochemical analysis. Sed+MCT showed decreased body weight, cross sectional area and MHC‐I isoform. Total Akt and mTOR protein levels were normal while its phosphorylated forms were increased in exercised groups. Increased Atrogin‐1 protein expression was found only in Sed+MCT, as well as higher serum levels of CRP and IL‐1b. The present study provides evidence that exercise preconditioning prevents cardiac cachexia by averting proteolysis and inflammation.