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Association between uric acid, lean mass, and muscle strength gains in the elderly
Author(s) -
Johannsen Neil Michael,
Welsch Michael A.,
Credeur Daniel,
Hollis Brandon,
Church Timothy S.,
Allen Jason D.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1077.6
Subject(s) - lean body mass , medicine , muscle strength , isometric exercise , zoology , strength training , uric acid , cardiology , muscle mass , physical therapy , body weight , biology
Purpose To examine associations between UA, lean mass, and muscle strength and determine the relationship between UA and strength gains with exercise training. Methods Fifty‐two older (70+y) men and women (n=33) completed 4 wk of aerobic endurance training (AET) or regional specific exercise (RSTS). Body composition was assessed by DXA and UA was measured enzymatically. Total strength was the sum of maximal isotonic (leg and chest press, seated row) and isometric handgrip strength. AET consisted of walking and biking, 3 d/wk (45 min/session; 50–85% of HRR) and RSTS of 8 exercises (15 contractions/min for 5 min starting at 40% MVC) including all major muscle groups. Results Mean±SD baseline age, weight, and UA levels were 74.9±4.4 y, 81.5±16.0 kg, and 5.8±1.2 mg/dl, resp. UA was associated with baseline body weight (r=0.48, P <0.001), lean mass (r=0.47, P <0.001), and strength (r=0.31, P =0.02). RSTS and men had greater strength gains ( P =0.02 and P =0.001). Baseline and sex adjusted change in strength was greater in RSTS participants in the highest tertile of baseline UA (43.4±17.7 kg; mean±95%CI) compared to the low (16.0±16.2 kg) and middle (16.3±15.5 kg) tertiles within RSTS and to AET participants in the high UA tertile (19.5±16.6 kg). Conclusion UA is associated with lean mass and muscle strength and, in individuals over 70y, high UA is associated with larger strength gains after RSTS independent of sex. Research support from NIH grant 1RC1AG035822‐01 (PI‐ Jason D. Allen, PhD).