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Artificial Selection for High Aerobic Capacity is Protective against Weight Gain via Thermogenesis?
Author(s) -
Torvinen Sira Maria,
Silvennoinen Mika,
Mikkonen Maria,
Koch Lauren G.,
Britton Steven L.,
Kainulainen Heikki
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1073.5
Subject(s) - thermogenesis , christian ministry , endocrinology , medicine , rectal temperature , aerobic capacity , weight loss , chemistry , glucose tolerance test , zoology , biology , obesity , insulin resistance , philosophy , theology
Higher spontaneous activity and non‐exercise activity thermogenesis (NEAT) contribute significantly to daily energy balance, body weight, and therefore in health. It was previously shown that, relative to body mass, rats selectively bred for high intrinsic aerobic capacity (HCR = high‐capacity runner) consume more energy and are more spontaneously active than low‐capacity runner (LCR) counterparts. We tested whether HCRs have higher rectal temperatures after 2 h fasting and during glucose tolerance test compared to LCRs. We studied 40 HCR/LCR female rats for the fasting condition, and 20 HCR/LCR female rats for the glucose tolerance test. Rats were from 27th generation of selection and aged 9 months. During the glucose tolerance test we controlled the spontaneous activity levels of the rats with ground reaction force recording. Our study revealed that after 2 h fasting HCRs had significantly higher rectal temperature compared to LCRs (p < 0.05). During glucose tolerance test the rectal temperature of HCRs was significantly higher compared to LCRs throughout the test protocol (p < 0.05). In the present study the spontaneous activity of HCRs was higher at the beginning (p < 0.05), but not at the end of the glucose tolerance test, suggesting that higher activity of HCR rats does not exclusively explain higher NEAT. This study was supported by the Ministry of Education (Finland) and the National Institute of Health.