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Effect of Epithelial Sodium Channel Blockade in Hypertensive Nigerians
Author(s) -
Elias Simiat Olanike,
Sofola Soga,
Jaja Smith
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1068.9
Subject(s) - nigerians , blockade , blood pressure , medicine , epithelial sodium channel , amiloride , sodium , endocrinology , chemistry , receptor , organic chemistry , political science , law
BACKGROUND Approximately 60% of hypertensive Nigerians are salt‐sensitive. The demonstration of genetic linkage between Liddle syndrome and epithelial sodium channel (ENaC) suggests the physiological involvement of ENaC in blood pressure regulation. OBJECTIVE To determine the effect of ENaC blockade on blood pressure in hypertensive Nigerians. METHODS Fifty‐three hypertensive subjects were recruited after ethical clearance was given by College of Medicine University of Lagos Research Grants and Experimentation Ethics Committee. Every subject gave an informed written consent. Blood pressure was determined at baseline and after salt‐loading with 200mmol/day of Na + for 5 days. After one week wash‐out period, the tests were repeated following ingestion of 200mmol/day of Na + plus amiloride 5mg daily for 5 days. RESULTS Blood pressure rose significantly following salt‐loading (SBP, 3.1±2.3%; p < 0.001; DBP 2.9±12.4%; p<0.001). Blockade with amiloride significantly reduced SBP by −7.0±1.4%; p<0.0001 and DBP by −8.5±1.7%; p < 0.0001. CONCLUSION There were pressor responses to acute salt‐loading in hypertensive Nigerians. Blockade of epithelial sodium channel led to significant fall in blood pressure.