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Heart Rate Variability in Patients with Type 2 Diabetes Mellitus
Author(s) -
Goit Rajesh Kumar,
Khadka Rita,
Sharma Sanjib Kumar,
Limbu Nirmala,
Paudel Bishnu Hari
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1057.27
Subject(s) - medicine , supine position , interquartile range , heart rate variability , poincaré plot , type 2 diabetes mellitus , heart rate , gastroenterology , cardiology , diabetes mellitus , endocrinology , blood pressure
Objective To study heart rate variability (HRV) in patients with type 2 diabetic mellitus (T2DM). Methods HRV of 60 patients with T2DM and 30 controls were assessed. Resting ECG at spontaneous respiration was recorded for 5 minutes in supine position. The data are expressed as median (interquartile range). The p value <0.05 was considered statistically significant. Results All the time domain measures SDNN [26 (15.5–35) vs 36 (30–40.25) ms, p=0.002], RMSSD [25.9 (11.95–40.45) vs 36.65 (27.05–44.13) ms, p=0.002], NN50 [13.5 (1–70) vs 58 (15.5–86.5) count, p=0.002] and pNN50 [3.5 (0.23–21.83) vs 16.4 (4.45–27.63) %, p=0.002] were significantly lower in T2DM. In frequency domain, LF power [81 (32–148.75) vs 126 (85.25–237.75) ms2, p=0.007], LF power [28.8 (20.78–36.13) vs 36.05 (24.6–43.5) %, p=0.008], HF power [81 (16.75–187.75) vs 182.5 (121.5–281.75) ms2, p=0.001] and HF power [42.15 (27.73–50.65) vs 51.6 (43.58–62.05) %, p=0.001] were significantly lower in T2DM whereas LF nu [45.25 (35.28–63.93) vs 44.65 (33.7–65.35)] and LF/HF ratio [0.776 (0.543–1.13) vs 0.7005 (0.397–0.999)] were comparable. In Poincare plot, SD1 [18.5 (8.73–28.98) vs 26.2 (19.33–31.65) ms, p=0.003] and SD2 [37 (26.13–51.18) vs 48.6(39.63–56.15) ms, p=0.002] were lower in T2DM. Conclusions Patients with T2DM have reduced cardiovascular autonomic control especially parasympathetic control.