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Aging Aggravates Cardiac Dysfunction in Severe, but not in Mild, Pressure‐Overload
Author(s) -
Boer Martine,
Deel Elza D.,
Hoeijmakers Jan H.J.,
Duncker Dirk J.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1054.5
Subject(s) - pressure overload , medicine , muscle hypertrophy , constriction , cardiology , heart failure , left ventricular hypertrophy , cardiac function curve , endocrinology , cardiac hypertrophy , blood pressure
The aging heart undergoes structural and functional alterations, that are reminiscent of changes observed in the failing heart, and which thus may increase the vulnerability of the aging heart to develop heart failure. To investigate the effect of aging on left ventricular (LV) hypertrophy and dysfunction we subjected mice at 3, 12 and 24 mo of age to 8 wk of pressure‐overload produced by transverse aortic constriction (TAC), either mild (mTAC) or severe (sTAC). Aging affected cardiac geometry and function in sham mice, demonstrated by increases in LV weight (~26%) and diameter (~8%) and by decreases in LVdP/dt at 40 mmHg (dP/dt P40 ) (~13%) and in dP/dt min (~26%) in 24 mo versus 3 mo old mice (all p<0.05). mTAC produced compensated LV hypertrophy (30–40%) with minimal signs of LV dysfunction, which was similar in all age groups. sTAC resulted in ~75% LV hypertrophy, LV dilation (~20%), global dysfunction and pulmonary congestion in all age groups. However, aging aggravated the responses to sTAC, demonstrated by a further decrease in dP/dt P40 (~30%) and dP/dt min (~30%) and elevation of lung fluid weight (~27%) and right ventricular weight (~31%) in 24 mo versus 3 mo old mice (all p<0.05). The TAC‐induced increase in expression of atrial natriuretic peptide (ANP) was also most pronounced in the older age groups. In conclusion, the effects of severe pressure‐overload on cardiac hypertrophy and function are aggravated by aging.