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Left ventricular longitudinal strain and strain rate are preload dependent
Author(s) -
Gao Zhaohui,
Drew Rachel C.,
Momen Afsana,
Ndukwu Ifesinachi,
Muller Matthew D.,
Mast Jessica,
Blaha Cheryl,
Leuenberger Urs A.,
Sinoway Lawrence I.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1054.2
Subject(s) - preload , strain (injury) , cardiology , strain rate , medicine , heart rate , stroke volume , diastole , speckle tracking echocardiography , blood pressure , hemodynamics , ejection fraction , materials science , heart failure , metallurgy
2D‐speckle tracking echocardiography (STE) derived strain and strain rate measurements have been proposed as potential non‐invasive measures of myocardial deformation and function. However, the effects of left ventricular (LV) loading conditions on 2D‐STE derived LV longitudinal strain and strain rate have not been elucidated. The aim of this study was to determine whether acute preload reduction by Lower Body Negative Pressure (LBNP) would alter 2D‐STE derived LV longitudinal strain and strain rate. LBNP varied between 0, −10, −20, −30, −40 and −50 mmHg (3 min/level) as strain and strain rate were assessed in 12 healthy individuals (26±1 yrs, 6 females and 6 males). Systolic peak strain (%), systolic (S‐Sr), early and late diastolic strain rate (E‐Sr and A‐Sr) were measured from standard LV apical views at each LBNP level. Compared to baseline, LBNP caused significant decreases in LV end‐diastolic volume ( P <0.05) and stroke volume ( P <0.01) while heart rate increased ( P <0.01). LV longitudinal strain and strain rate decreased at LBNP ≥ −40 mmHg. Our results indicate that 2D STE‐derived longitudinal strain and strain rate are sensitive to acute preload changes. Thus, the effects of preload should be considered when strain and strain rate are used as indices of systolic and diastolic function. Supported by P01 HL096570 (LIS) ; UL1 RR033184 (LIS) .