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Rutin Supplementation on Cholesterol Metabolism in Female Albino Wistar Rats Using High‐Cholesterol‐Diet Model: Possible Renal Protection
Author(s) -
AL-REJAIE SALIM S.,
Abuohashish Hatem M.,
Alroujayee Abdulaziz S.,
Aleisa Abdulaziz M.,
Alkhamees Osama
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1051.4
Subject(s) - endocrinology , medicine , cholesterol , tbars , chemistry , ascorbic acid , kidney , rutin , oxidative stress , excretion , antioxidant , biology , lipid peroxidation , biochemistry , food science
This study was designed to investigate the effects of rutin (RT) and ascorbic acid (AA) combination on oxidative stress‐induced by high‐cholesterol‐diet (HCD) supplementation in the kidney of female Wistar albino rats. Feeding cholesterol increased serum total cholesterol (TC), triglycerides (TG), LDL and decreased HDL levels as compared to control diet. Treatments with RT, AA and their combination significantly decreased the TC, TG and LDL levels while increasing HDL levels. Nucleic acids (DNA and RNA), total protein and GSH concentrations were significantly decreased while TC, TG and TBARs levels were increased in kidney tissues of hypercholesterolaemic diet‐fed rats. The supplementation of RT and AA combination brought back the changes‐induced by the HCD to normal level. However, the correction of changes in all parameters showed more significant in RT and AA combined therapy than the individual treatments. These results suggest that the supplementation of RT (vitamin‐P) and AA (vitamin‐C) promoted the excretion of fecal sterols, thereby leading to a decreased absorption of dietary cholesterol as well as lower plasma and tissues cholesterol.