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Evaluation of aminoglycosides‐induced cardiotoxicity in zebrafish obtained in a low cost facility
Author(s) -
Vargas Rafael Antonio
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1050.6
Subject(s) - zebrafish , cardiotoxicity , pharmacology , cardiac function curve , medicine , function (biology) , toxicity , biology , microbiology and biotechnology , heart failure , biochemistry , gene
Zebrafish is a popular model in basic medical sciences research since middle eighties. Cardiovascular research has been made in larvae and adults and different aspects of cardiovascular development and physiology has been described. Zebrafish heart is sensible to external chemicals agents and cardiac alterations in shape and function could be observed under conventional microscopy. Currently, we describe the set up of a low cost, custom‐built facility to produce zebrafish. In addition, we explore toxicity of aminoglycosides on cardiac activity of transparent zebrafish larvae. We have found that some aminoglycosides can cause arrhythmic activity at high doses. This effect has some similarities to the arrhythmogenic effect caused by classical antiarrhythmic drugs. Use of zebrafish as a model to investigate pharmacological and toxicological properties of different drugs could be an inexpensive, an ideal model, which could be an advantage for researchers in undeveloped countries where to obtain financial aid, in many cases, is too complicated.