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Magnesium Oxide Nanoparticles Induce Cytotoxic and Proinflammatory Effects in Schwann cells and DRG Neurons
Author(s) -
Idikuda Vinaykumar,
Jaiswal Ashvin,
wong Yin Yin wendy,
leung solomon,
Daniels christopher,
lai james
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1046.3
Subject(s) - dorsal root ganglion , cytotoxic t cell , proinflammatory cytokine , chemistry , microbiology and biotechnology , in vitro , biophysics , immunology , inflammation , spinal cord , neuroscience , medicine , biology , biochemistry
Applications of metal oxide nanoparticles in diverse fields have been accelerating in the last decade. For example, magnesium oxide (MgO) nanoparticles have been employed in ceramics, and as adhesive and additive in chemical raw materials, leading to their increased human exposure, thereby posing potential health hazards. We have therefore investigated the hypothesis that MgO nanoparticles exert differential cytotoxic effects on neural cells in the peripheral nervous system employing cell models consisting of Schwann cells and dorsal root ganglion neurons (DRG) in vitro. Results of our ongoing studies revealed MgO nanoparticles exerted differential effects on lowering the survival of Schwann cells and DRG neurons. Along with their morphological changes, we also found the nanoparticles induced differential dose‐related increases in expression of markers of inflammatory responses such as Interleukin‐6 (IL‐6) and Peroxisome Proliferated Activated Receptor PPAR‐? in the two neural cell types. Thus, our results suggest that MgO nanoparticles can induce differential cytotoxic effects and elicit inflammatory responses in Schwann cells and DRG neurons and as such may have implications in health hazard of human exposure to the nanoparticles. Supported by: USAMRMC project grant (contract#W81xWH‐07‐2‐0078) and NIH grant #P20 RR016454 from Idaho INBRE program of the National Center for Research Resources.