Premium
Interactions between the orphan receptor GPR37L1 and the dopamine D1 receptor
Author(s) -
Meyer Rebecca,
Hall Randy A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1044.5
Subject(s) - dopaminergic , g protein coupled receptor , dopamine receptor , dopamine receptor d2 , receptor , orphan receptor , neuroscience , crosstalk , dopamine , dopamine receptor d3 , biology , d2 like receptor , pharmacology , genetics , physics , transcription factor , gene , optics
Studies on receptor‐receptor interactions between GPCRs provide valuable insight into crosstalk among different signaling pathways and also indicate potential novel pharmacological targets. The dopaminergic system is of particular pharmacological interest due to its importance in numerous disorders in the central nervous system, including drug abuse and Parkinson's disease. Our lab has been investigating the modulation of dopaminergic receptors through interactions with the orphan GPCR sub‐family GPR37 and GPR37L1. These receptors are highly expressed in dopaminergic areas of the brain and previous work from our lab has indicated that GPR37 is able to physically interact with dopaminergic D2 receptors to alter D2 receptor pharmacological properties. In new studies, we have found that GPR37 does not associate with dopamine D1 receptors; however the closely related GPR37L1 shows a robust D1 receptor interaction. This results in significant changes in D1 receptor function, including alterations in G protein coupling and other signaling properties. In ongoing studies, we are further exploring this novel receptor‐receptor association and its role in both normal and aberrant dopaminergic signaling. This work was supported by NIH R01 NSO55179 .