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Investigation of the role of corticotropin‐releasing factor receptors within the central amygdala and basolateral amygdala during nicotine withdrawal in rats
Author(s) -
Ji Yue,
Alexander Jon C.,
Bruijnzeel Adrie
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1039.5
Subject(s) - amygdala , basolateral amygdala , nicotine , anxiety , psychology , brain stimulation reward , stimulation , mood , addiction , kindling , nicotine withdrawal , antagonist , neuroscience , medicine , central nervous system , receptor , psychiatry , nucleus accumbens
Abrupt cessation of tobacco smoking in humans is associated with negative affective symptoms such as depressed mood and anxiety. Evidence indicates that this dysphoric state associated with nicotine withdrawal is one of the motivational factors for the continuation of tobacco smoking. Cessation of chronic nicotine administration in rodents induces affective withdrawal signs which can be investigated using the intracranial self‐stimulation (ICSS) procedure. The amygdala is hypothesized to play a key role in both the positive and negative reinforcing properties of drugs of abuse. Injections of the specific CRF1 antagonist R278995/CRA0450 into the central amygdala attenuated elevations in brain reward thresholds, whereas injections into the basolateral amygdala showed no effect. Funded by NIDA Grant # DA023575