Premium
Assessment of iron status and biomarkers of inflammation in schoolchildren with and without infection
Author(s) -
Grijalva Maria Isabel,
Garcia Karla Fabiola,
Artalejo Elizabeth,
Caire Graciela
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1033.8
Subject(s) - soluble transferrin receptor , iron deficiency , ferritin , inflammation , medicine , immunology , anemia , transferrin , hemoglobin , zinc protoporphyrin , serum iron , iron status , acute phase protein , gastroenterology , physiology , biology , heme , biochemistry , enzyme
Iron deficiency is the most prevalent nutritional disorder in the world and the leading cause of anemia in children; it often occurs in populations with a high prevalence of chronic and/or repeated acute infections associated with chronic inflammation. Objetive To evaluate the iron deficiency in schoolchildren by serum ferritin (SF), protoporphyrin and serum transferrin receptor (sTfR) in the presence or absence of infection. Subjects and Methods A crossectional study was performed in 195 children of 5 to 11 years old. Hemoglobin (Hb), SF, protoporphyrin and sTfR were measured, as well as the inflammation biomarkers á1‐acid glycoprotein (AGP) and C‐reactive protein (PCR), to associate iron‐status indicators with the inflammatory process. Results The prevalence of anemia (Hb <11.5 g/dL) was 5%. However, a 77% of iron deficiency was detected through serum ferritin. The values of RsTf and protoporphyrin were normal, indicating that the children were in the stage I of iron status. Despite this, SF correlated positively with PCR (r=0.178, p<0.05) but not with AGP (r=0.054, p=0.449). Correlations between RsTf and the markers of inflammation, AGP and PCR, were not statistically significant (P<0.05). Conclusion The markers of inflammation did not influence the analysis of ferritin for the detection of iron deficiency.