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Differential protective effects of alginate and fucoidan from the edible algae on the ethanol‐induced liver damage
Author(s) -
Namkoog Seung,
Kim Ye-Jin,
Kim Taeseong,
Kim Jeung-eun,
Lee Jimin,
Ro Hyo-Lyun,
Sohn Eun-Hwa
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1033.7
Subject(s) - fucoidan , ethanol , chemistry , toxicity , fibrosis , liver injury , pharmacology , liver toxicity , fatty liver , brown algae , brown seaweed , algae , biochemistry , polysaccharide , biology , medicine , botany , disease , organic chemistry
Alcohol‐induced liver injury progresses from fatty infiltration followed by a harmful cause of inflammation leading to an irreversible damage. In this study, two compounds (alginate and fucoidan) isolated from marine edible brown algae were examined for their protective effects against ethanol‐induced toxicity in vitro. Ethanol‐induced HepG2 cells were treated with the compounds at various concentrations, and the results showed that fucoidan at 50 μg/mL was decreased TGF‐β expression, a hallmark of liver fibrosis, and iNOS expression. The administration of 60 mg/kg of fucoidan resulted in the reduction of sGOT and sGPT levels caused by 25% ethanol exposure (2.0 g/kg/day, po) for 5 days in mice. However, alginate unexpectedly enhanced the iNOS and TGF‐β expression in HepG2 cells. These findings suggest that fucoidan could be a potential candidate for attenuated of ethanol induced liver damage.