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Inflammation, weight status, and iron status in Mexican children in a randomized controlled iron‐biofortified bean feeding trial
Author(s) -
Luna Sarah,
Villalpando Salvador,
Shamah Teresa,
Boy Erick,
Haas Jere D.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1031.15
Subject(s) - overweight , ferritin , iron deficiency , medicine , obesity , placebo , hemoglobin , c reactive protein , inflammation , randomized controlled trial , anemia , gastroenterology , pathology , alternative medicine
Overweight is increasing in transition countries, but iron deficiency remains prevalent. Ferritin is a common marker or iron stores; however, in populations with chronic inflammation, ferritin values may be artificially increased in the presence of real iron deficiency. This study examines the relationship between BMI and markers of iron status and inflammation in children age 9–12 (n = 347) using data from a randomized, placebo‐controlled trial of iron biofortified beans in 20 Mexican boarding schools. Dependent variables are iron status (hemoglobin, ferritin, and sTfR) expressed as continuous or categorical variables (iron deficient and anemic). BMI is expressed as a continuous or categorical variable (normal, overweight, obese). Inflammation was assessed by CRP and AGP. Covariates, such as age, sex, school, amount of fortified beans consumed were controlled. Overweight was observed in 17.6% of the children, 13.5% were anemic (hemoglobin <120 g/L), 9.8% had elevated CRP (>3 mg/L) and 11.0% had elevated AGP (>1 g/L). Inflammation status of the school, obesity, and individual baseline CRP predicted elevated ferritin at baseline (p =0.003; p=0.022; p<0.001, respectively). In boarding schools given the control beans, those with high morbidity showed a positive change from baseline in corrected log ferritin (p = 0.0074) compared to those with low morbidity. Supported by HarvestPlus and AgroSalud