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Association of vitamin D levels to blood pressure among blacks and whites
Author(s) -
Sakamoto Rose O,
Tonstad Serena,
Jaceldo-Siegl Karen,
Haddad Ella,
Oda Keiji,
Fraser Gary
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1026.3
Subject(s) - medicine , blood pressure , waist , vitamin d and neurology , anthropometry , cohort , body mass index , demography , diastole , cohort study , sociology
Cardiovascular risk factors such as hypertension remain a huge health burden and Blacks have been recognized to have higher prevalence of hypertension compared to non‐Hispanic Whites. The relationship of vitamin D [25(OH)D] to blood pressure among biethnic cohort remains unclear. Utilized cross‐sectional design based on data of the calibration sub‐study of the Adventist Health Study −2 (AHS‐2) cohort: 284 Whites and 284 Blacks. Participants attended clinics during which anthropometric and blood pressure were measured, food‐frequency questionnaires completed and fasting blood samples were obtained in 2003–2007. Multiple regression analyses were used to assess independent relationships between blood pressure and 25(OH)D levels. After control for age, gender, BMI, and use of BP‐lowering medications, levels of 25(OH)D were inversely associated with systolic BP in Whites (β‐coefficient −0.23 [95% CI, −0.43, −0.03; p = .02]). This relationship was not seen in Blacks (β‐coefficient 0.08 [95% CI, −0.14, 0.30; p = .4]). Results were similar when controlling for waist circumference or percentage body fat instead of BMI. No relationship between serum 25(OH)D and diastolic BP noted. Systolic BP is inversely associated with 25(OH)D levels in Whites but not in Blacks. Vitamin D may not be a major contributor to the White‐Black differential in BP. Research supported by the Glen Blix Foundation and AHS‐2 Seed Grant.