Premium
Effect of Soy Nut dietary intervention on cardiovascular disease biomarkers in adults with cardiometabolic syndrome
Author(s) -
LaSalle Colette D,
Reverri Elizabeth J,
Kappagoda C Tissa,
Steinberg Francene M
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1026.19
Subject(s) - isoflavones , soy protein , medicine , metabolic syndrome , crossover study , cholesterol , food science , endocrinology , obesity , chemistry , alternative medicine , pathology , placebo
Intake of bioactive compounds (such as isoflavones in soy) has been shown to ameliorate cardiovascular dysfunction. Consumption of soy products is correlated with improvement of lipid profiles, oxidative reactions and vascular functions. This study aimed to determine effects of soy nut intake on biochemical risk factors associated with cardiometabolic syndrome. The ongoing randomized controlled crossover study has completed 14 of the 18 planned subjects. Each 4 week intervention included either 70 g/d soy nuts (101 mg isoflavones) or milk‐protein based nutrient matched food, with treatments separated by a 2 wk washout period. Plasma levels of VCAM, ApoB100, oxidized LDL, lipid panel and clinical labs were measured. Based on preliminary analyses of the first 9 (3M, 6F; Age 55 ±4.8; yrs; BMI 30.3 ± 2.3) subjects (meeting Metabolic Syndrome criteria) soy nut treatment resulted in non significant reduction in glucose and calcium. The matched food led to significant decreases in cholesterol and serum calcium with a trend for reduced systolic blood pressure. Both treatments produced a significant decrease in uric acid. Initial results suggest that clinical lab values remained within normal limits and neither soy nor the matched food were significantly better at reducing biomarkers of lipid metabolism and endothelial function in cardiometabolic syndrome. Support: Departmental research funds