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Effect of Ginkgo biloba leaves on plasma and liver lipids, platelet aggregation and erythrocyte Na+ efflux channels in ovariectomized rats
Author(s) -
Ryou Sung-Hee,
Kang Young-Hee,
Kang Jung-Sook
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1026.10
Subject(s) - ovariectomized rat , chemistry , triglyceride , endocrinology , medicine , ginkgo biloba , intracellular , cholesterol , platelet , efflux , pharmacology , biochemistry , biology , hormone
Forty 9 weeks old OVX rats ovariectomized at age of 5 weeks were divided into 4 groups and fed 0.2% cholesterol based control diet, 10% Ginkgo biloba (Gb) leaves powder, 3% Gb extract and 1% tanamin (EGb761) for four weeks. Total cholesterol and HDL cholesterol were significantly increased in rats fed diet with tanamin compared with the control (both p<0.01) with no difference in liver cholesterol. Liver triglyceride was decreased in Gb leave powder compared with no difference in plasma TG. Platelet aggregation in the maximum and the initial slope tended to increase in groups with Gb powder, Gb extract and tanamin compared with the control. Intracellular Na was increased in group with tamanin compared with other groups (p<0.05), and with no difference in intracellular K. Na‐K ATPase in group with Gb powder and Na cotransport in group with Gb extract were significantly increased compared with the control (both, p<0.05). Angiotesin converting enzyme (ACE) was significantly decreased in group with tanamin (p<0.05) and ACE activity was not correlated with any of Na efflux channels. Bioactive compounds in gingko biloba in forms of powder, extract or tanamin (EGb761) seemed to play some roles on platelet aggregation and RBC efflux channels. Further studies including invitro experiment may be required for interpretation on their beneficial effects