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Extracts of germinated wheat and barley reduce postprandial hyperglycemia by inhibiting α‐glucosidase in diabetic db/db mice
Author(s) -
Jang Hae-Dong,
Zhou Bing,
Kwon Young-In
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1025.16
Subject(s) - maltase , acarbose , sucrase , maltose , postprandial , alpha glucosidase , sucrose , chemistry , food science , starch , blood sugar , diabetes mellitus , endocrinology , biochemistry , medicine , enzyme
Extracts of germinated wheat and barley (EGW and EGB) were investigated as a potent cereal‐derived α–glucosidase inhibitor in diabetic db/db mice. They were prepared by soaking in distilled water with 0.5% tea catechin and 1% chitinoligosaccharide for 24 hr, extracting with autoclaving at 121 °C for 15 min, and freeze drying. The in vitro inhibitory activity of EGW and EGB on intestinal α–glucosidase, sucrase, and maltase was relatively weak compared to acarbose used as a positive control. However, sugar loading test with starch, sucrose, and maltose showed that significantly reduced postprandial increases in blood glucose, indicating that they may act as an intestinal α–glucosidase, sucrase, and maltase inhibitor. These results suggests that EGW and EGB could be used in the development of nutraceutical foods to control the blood glucose levels of diabetic patients by inhibiting intestinal α–glucosidase with reduced side effects. Grant Funding Source : ASN