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Lipocalin‐2 Serum Levels Decrease in a Randomized Dietary Feasibility Study for Stage II‐IV Ovarian Cancer Survivors
Author(s) -
Garcia-Prieto Celia,
Paxton Raheem,
Berglund Maria,
Hernandez Mike,
Hajek Richard A.,
Handy Beverly C.,
Brown Jubilee,
Jones Lovell A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1024.1
Subject(s) - lipocalin , medicine , body mass index , ovarian cancer , randomized controlled trial , cancer , physiology , gastroenterology , endocrinology , zoology , biology
Background Lipocalin 2 has been shown to be up‐regulated in ovarian cancers and correlated with disease progression but the role of fruit and vegetable consumption on serum levels in ovarian cancer survivors has not been studied. Methods In a randomized design, women diagnosed with stage II‐IV ovarian cancer were assigned to a low fat, high fiber diet or a modified National Cancer Institute diet supplemented with a soy‐based beverage and encapsulated fruit and vegetable juice concentrates (FVJCs). Blood samples were collected at 0, 3, 6 months and serum levels of lipocalin‐2 were determined using highly sensitive immunoassays. Results The FVJC dietary intervention significantly lowered lipocalin‐2 serum levels compared to LFHF after 6 months (P<0.05). Those participants in the FVJC group above the average age and with no history of oral contraceptive use experienced the most significant decreases (P<0.05). Correlations between lipocalin‐2 levels with body mass index, or CA‐125 did not indicate significance. Conclusion These results show evidence that a low fat, high fiber diet supplemented with fruit and vegetable juice concentrates can cause decreases in lipocalin‐2 serum levels after 6 months of consumption and suggest further studies are necessary to investigate mechanism.