Premium
Vitamin D supplementation and muscle responses in early pubertal adolescents
Author(s) -
Wright Christian,
Laing Emma,
Williams Jamie,
Pollock Norman,
Hausman Dorothy,
Weaver Connie,
Martin Berdine,
McCabe George,
Peacock Munro,
Warden Stuart,
Hill Kathleen,
Lewis Richard
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1021.9
Subject(s) - medicine , vitamin d and neurology , endocrinology , quantitative computed tomography , parathyroid hormone , muscle mass , vitamin d deficiency , bone mineral , osteoporosis , calcium
Though studies in older adults suggest that vitamin D supplementation improves muscle mass and strength, pediatric data are scant and equivocal. We determined the dose‐response effect of oral vitamin D on muscle parameters in 320 early pubertal (9–13 y), male and female, black and white children recruited from US latitudes 34°N and 40°N, and randomly assigned to five experimental conditions: 0, 400, 1000, 2000 or 4000 IU/d vitamin D3 for 12 wks (in winter). Muscle parameters [Fat‐free soft tissue (FFST) by dual‐energy X‐ray absorptiometry, cross‐sectional muscle area (MSCA) and muscle density by peripheral quantitative computed tomography, forearm strength by hand‐grip dynamometry] and serum [25(OH)D by RIA, parathyroid hormone (PTH) by IRMA] were measured at baseline and 12 wks. Though FFST and radial and tibial MCSA increased over 12 wks (time effect, p<.01), there was no dose‐response effect of vitamin D on muscle parameters. Partial correlations adjusting for race and sex revealed that 12‐wk changes in (Δ) PTH were positively associated with ΔFFST (r=.21; p=.03) and Δtibial MCSA (r=.23; p=.02). Δ25(OH)D was not associated with Δmuscle parameters. Our data suggest that 12 wks of vitamin D supplementation does not affect muscle mass and strength in early pubertal children. Whether the observations with respect to PTH and muscle are clinically relevant should be further explored. Supported by NICHD, R01HD057126.