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Multivitamin (MVT) use, alcohol intake, and oxidative stress (OS) in HIV+ individuals on antiretroviral therapy (ART)
Author(s) -
Stewart Tiffanie,
Campa Adriana,
Shin Dong-Ho,
Martinez Sabrina Sales,
Li Yinghui,
Williams Shawn,
Barr Shakira,
Parsons Mary,
Farsad Mahsa,
Hatsu Irene,
Luisi Sonya,
Martinez Celines,
Oropeza Monica,
Ramamoorthy Venkataraghavan,
Baum Marianna K
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1021.17
Subject(s) - medicine , alcohol , glutathione , oxidative stress , viral load , multivitamin , alcohol intake , gastroenterology , human immunodeficiency virus (hiv) , immunology , chemistry , biochemistry , vitamin , enzyme
Background HIV disease, excessive alcohol use and ART have been associated with oxidative stress (OS). This cross‐sectional study examines the effect of reported MVT supplements and alcohol intake on OS and disease stage. Methods Alcohol intake, MVT use, and markers of OS (% oxidized glutathione) and disease stage (CD4 count, viral load) were collected in 89 HIV+ participants on ART. Linear regressions, correlations and Student's‐t tests were used in analyses. Results HIV+ adults with hazardous alcohol intake (AUDIT score >8), who also used MVT had significantly lower % oxidized glutathione than those not taking MVT (21.9% vs 25.2%, p=0.037). However, there were no significant differences in % of oxidized glutathione by MVT in those who abstained or drank alcohol in moderation. Greater alcohol intake was significantly associated with higher % oxidized glutathione (β=0.23, p=0.009) and use of MVT with lower % of oxidized glutathione (β=−3.6, p=0.005), when controlling for age and gender. In those who used MVT, hazardous drinking was correlated with viral load (r=0.430, p=0.001) and CD4 count (r=−0.457, p=0.001). Conclusion HIV+ adults with hazardous alcohol drinking present significantly greater OS. Our findings suggest that in HIV+ adults, MVT supplements ameliorate OS. However, despite MVT supplementation, those with hazardous drinking showed more advanced disease. Funded by NIDA and NIAAA