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Changes in lipid soluble antioxidants after computer tomography in children
Author(s) -
Franke Adrian A.,
Halm Brunhild M,
Lai Jennifer F,
Morrison Cynthia M,
Custer Laurie J,
Cooney Robert V
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1017.8
Subject(s) - coenzyme q10 , lutein , carotenoid , antioxidant , medicine , zeaxanthin , ionizing radiation , nuclear medicine , chemistry , biochemistry , irradiation , physics , nuclear physics
Objective Computer tomography (CT) involves ionizing Xray‐radiation which can form free radicals. CT use has risen dramatically due to its high speed and diagnostic value but it leads to an estimated lifetime cancer risk of up to 4% with highest risk for children. We tested whether free radical scavenging antioxidant levels in children change after CT. Methods 17 children aged 0.25–6 years and scheduled for medically indicated CT donated blood immediately before and 1 hour after a CT exam (93–526 mGy cm). Blood was immediately processed after the second blood draw and heparin plasma was frozen until analysis. HPLC with photodiode‐array (carotenoids, tocopherols, retinols) or electrochemical (coenzyme Q10) detection was applied. Significance was determined by paired t‐tests. Results In post versus pre CT plasma levels of carotenoids increased: lutein/zeaxanthin (−4%), cryptoxanthins (−8%), lycopenes (−8%), and total carotenes (−8%), as did those for tocopherols (a, −6%; B+y, −6%). Reduced (+24%), oxidized (+8%), and total (+22%) Q10 levels were higher (p>0.1) and retinol level was unchanged. After data were logged only cryptoxanthins and lycopenes lost significance. Conclusions The decrease of main lipid soluble antioxidants after CT in children may be due to free radical scavenging, thereby preventing damage. The increase in plasma Q10 levels after CT could be due to greater cell death.