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Variability of Oxidant Status in Women of Childbearing Potential
Author(s) -
Artz Tamara,
Jalili Thunder,
Goodman Michael,
Murtaugh Maureen A
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1017.4
Subject(s) - medicine , urine , pregnancy , physiology , vitamin e , vitamin c , vitamin , glutathione reductase , urinary system , obstetrics , gynecology , glutathione peroxidase , biology , oxidative stress , antioxidant , biochemistry , genetics , catalase
Objective Oxidant status may influence conception after in vitro fertilization, maternal health during pregnancy, and fetal outcomes including birthweight. However, few reports exist of oxidant status in women of childbearing potential. Therefore, we describe the range of oxidant status in a group of potentially fertile women (n=96). Methods We conducted a cross‐sectional study of dietary supplement intake and blood and urine biomarkers of oxidative status (serum total glutathione (TGLUT) Oxis Research and urinary 8‐isoprostane (8‐ISO) Cayman Chemical Co. Statistics were run using SAS version 9.2 using log transformed variables where appropriate. Results Women averaged 31 years (range 18 – 49, sd=8.5) with up to 4 live births. Sixty‐one women reported using any supplement, 23 used multivitamins and 11 prenatal vitamins. TGLUT varied four fold (mean=818.0 uM, 95%CI=201.5–1907.8). Urine 8‐ISO varied 80‐fold (mean=115.0 pg/mL, 95%CI=4.5–458.5T). TGLUT and 8‐ISO were positively correlated (r=0.24, p<0.02). TGLUT was higher among women using vitamin C, vitamin E, lutein, lycopene, carotenoids (p=0.03) vs. non‐users. Conclusions The positive correlation of vitamin C supplementation with total glutathione concentrations suggests that vitamin C may be an effective strategy for augmenting plasma glutathione in women of childbearing potential.