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Polymorphisms in FADS2 correlated with altered desaturase activity in a type‐2 diabetic cohort
Author(s) -
Huang Pei-Chi,
Jhang Huei-Ru,
Hsu Chih-Cheng,
Kothapalli Kumar,
Brenna Tom,
Huang Meng-Chuan
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1016.7
Subject(s) - fads2 , single nucleotide polymorphism , medicine , snp , genotype , type 2 diabetes , fatty acid , endocrinology , fatty acid desaturase , cohort , chemistry , allele , biology , diabetes mellitus , polyunsaturated fatty acid , biochemistry , gene , docosahexaenoic acid
Recent evidence reveals that single nucleotide polymorphisms (SNP) in fatty acid desaturase 2 (FADS2) is correlated with alteration in blood fatty acid profile in some ethnic groups. We aimed to examine effects of FADS2 (intronic SNP, rs174589 ) on Δ6 and Δ5 desaturase activities based on ratios of 18:3n‐6/18:2n‐6 and 20:4n‐6/20:3n‐6 respectively. In 2008, we cross‐sectionally analyzed erythrocyte fatty acids in type 2 diabetic patients (n=702) recruited from the Diabetes Management through Integrated Delivery System (DMIDS) cohort established in Taiwan. Frequencies of rs174589 genotypes GG, GC and CC were 0.739, 0.234 and 0.027 respectively. Levels of hemoglobin A1c in CC genotypes were significantly different from those of GC and GG genotypes. Δ6 desaturase activity (18:3n‐6/18:2n‐6) was significantly reduced in GC (0.005±0.003, p=0.003) and CC (0.004±0.003, p=0.025) than GG genotypes (0.006±0.003). Similarly, Δ5 desaturase activity (20:4n‐6/20:3n‐6) was significantly diminished in C allele carriers than the GG homozygotes (p<0.05). In conclusion, rs174589 in FADS2 is associated with Δ6 and Δ5 desaturase activities in type 2 diabetes patients and impact of these alterations in fatty acids profiles on clinical parameters warrants further investigation.