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Association between erythrocyte n‐3 fatty acid levels and the risk of depression: case‐control study in Korea
Author(s) -
Park Yongsoon
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1016.1
Subject(s) - confounding , depression (economics) , medicine , polyunsaturated fatty acid , epidemiology , fatty acid , demography , physiology , biology , biochemistry , economics , macroeconomics , sociology
The purpose of the present study was to evaluate hypothesis that erythrocyte level of n‐3 PUFA and seafood intake were negatively associated with the risk of depression in Koreans. Eighty cases were consisted of patients diagnosed with depression Center for Epidemiological Studies Depression Scale Korea version (CES‐D‐K) score ¡Ã25 and confirmed by a psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Eighty eight controls were age‐and sex‐matched to the cases, and without a chronic disease. Multivariate‐adjusted regression analysis showed that the risk of depression was negatively associated with erythrocyte levels of 18:3n3, 20:5n3, 20:6n3, 16:0 and 18:0, but positively associated with erythrocyte level of 18:2t after adjusting for confounding factors. The risk of depression was also negatively associated with the intake of energy, carbohydrate, seafood and grains, but positively with the intake of fat and meat after adjusted for confounding factors including energy intake. Correlation analysis consistently showed similar results with CES‐D‐K score. In conclusion, high levels of n‐3 PUFA and saturated fatty acids, and intake of seafood and grain decreased, but level of trans‐fatty acid, and intake of fat and meat increased the risk of depression in this population. (This work was supported by the Korea Research Foundation Grant 2009‐0065576)