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Contribution of total and central adiposity to systemic adipokines during weight loss
Author(s) -
Gletsu-Miller Nana,
Lin Edward
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1012.7
Subject(s) - adipokine , leptin , adiponectin , adipose tissue , medicine , weight loss , endocrinology , body mass index , obesity , insulin resistance
Total and central adiposity is linked with disease risk through the activation of inflammatory pathways, but the contribution of fat depots to systemic concentrations of pro‐ and anti‐inflammatory cytokines is unclear. Objectives were to determine associations among measures of total (TAT), abdominal visceral (VAT) and subcutaneous adipose tissue (SAT), and plasma concentrations of leptin, C‐reactive protein (CRP), and adiponectin in severely‐obese women (N = 48) during weight loss for 6 months following gastric bypass surgery. TAT was assessed using air‐displacement plethysmography; VAT and SAT using computed tomography; cytokines using enzyme‐linked immunoassay. Body mass index decreased from baseline to 6 months (46.3±0.7, 34.8±0.7kg/m 2 ), primarily due to decreases in TAT (69.7±1.8, 42.7±1.5kg), VAT (4,160±240, 2,510±180cm 3 ) and SAT (14,320±500, 9,280±390cm 3 ) (all P<0.05). Plasma concentrations of CRP (1.29±0.13, 0.58±0.08mg/dL) and leptin (134.7±9.2, 49.0ng/mL) decreased, and adiponectin increased (6.10±0.5, 8.04±0.7ng/L). At baseline and at 6 months following weight loss, there were strong correlations between CRP and TAT (r = 0.36 and 0.38, respectively), and SAT (r = 0.46 and 0.42) but not VAT. For leptin, correlations were observed with TAT only, at both timepoints (r = 0.48 and 0.87). For adiponectin, negative correlations were observed with TAT and SAT (r = −0.42 and −0.46) but not VAT, at 6 months. No longitudinal relationships were found between adipose tissue and cytokine concentrations. In conclusion, TAT and abdominal SAT were more strongly associated with systemic CRP, leptin, and adiponectin concentrations compared to VAT. Future studies should clarify the contribution of regional versus total adiposity to systemic inflammation.