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Relationship between adipokines, lipid profile, and insulin sensitivity in older African Americans: Adiponectin as a potential cardioprotective mediator
Author(s) -
Lemacks Jennifer Lynn,
Ernst Jasminka Ilich,
Ralston Penny A.,
Coccia Catherine,
Young-Clark Iris,
Wickrama Kandauda,
Harris Cynthia M.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1012.5
Subject(s) - adiponectin , adipokine , medicine , endocrinology , leptin , lipid profile , insulin sensitivity , insulin , insulin resistance , obesity , diabetes mellitus
Research examining endocrine communication involving leptin, adiponectin and obesity in African Americans (AAs) is sparse. Our objective was to examine relationships between lipid profile (HDL, LDL, TotalChol, TG, VLDL), insulin sensitivity (by QUICKI), and adipokines in 71 mid‐life/older African Americans enrolled in a church‐based health intervention project. Participants were (MEAN±SD) 59.5±10.1y old with BMI 34.9±9.2kg/m2, and 73% female. Log‐transformed variables were utilized in calculations and the data were analyzed using SPSS19.0. Pearson's correlations revealed association between adiponectin and HDL (r=0.26, p=0.03), TG (r=−0.32, p<0.01), and QUICKI (r=0.48, p<0.001); as well as leptin and LDL (r=−0.21, p=0.07) after controlling for BMI, age, and gender. Regression analysis revealed adiponectin to be a significant predictor of HDL (β=0.28, p<0.01) and TG (β=−0.36, p=0.001), after controlling for BMI, age, and gender. Adiponectin was also a significant predictor of QUICKI (β=0.24, p=0.01) after controlling for BMI, age, gender, insulin, and glucose levels. There were no relationships between leptin, lipid profile, and insulin sensitivity. Based on these results, adiponectin may have cardioprotective benefits as an endocrine mediator by improving insulin sensitivity and lipid profile in older AAs. Funded by: NIH Institute on Minority Health & Health Disparities (R24MD002807‐02) Grant Funding Source : NIH