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Effects of Isoflavones Supplements and Exercise on Biomarkers of CVD in Korean Postmenopausal Women
Author(s) -
Lee HanSongYi,
Kim Jinkyung,
Lee Okhwa,
Choue Ryowon
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1008.3
Subject(s) - medicine , isoflavones , placebo , postmenopausal women , menopause , endocrinology , blood lipids , randomized controlled trial , physiology , cholesterol , alternative medicine , pathology
The objective of this study was to assess the combined effects of isoflavones supplements (70 mg/d of isoflavones) and exercise (81 min/day) in Korean postmenopausal women. We recruited postmenopausal women who were free of diagnosed cardiovascular disease (KMC IRB 1002‐02). In this double‐blind randomized controlled trial, 67 postmenopausal women were assigned to four groups: 1. Placebo (PLA, n=9) 2. Isoflavone supplements (ISO, n=11), 3. Exercise and placebo (Ex+PLA, n=25), 4. Exercise and isoflavone supplements (Ex+ISO, n=22). Dietary isoflavones intakes were analyzed by a 3‐day food records. Blood levels of lipids, insulin, glucose, hormones, hs‐CRP, sVCAM, and sI‐CAM were analyzed at baseline and 12 weeks. The average age and menopausal period were not different among the groups. The levels of total and LDL‐chol in the PLA were significantly higher than in the ISO, Ex+PLA, and Ex+ISO groups (p<.05). Levels of hs‐CRP, sICAM‐1 and sVCAM‐1 were not different among the groups. However, sICAM‐1 levels increased after supplementation, in the Ex+ISO group and sVCAM‐1 levels reduced after supplementation, in the ISO group (p<.05). In conclusion, isoflavone supplements and exercise for 12 weeks prevented the increased levels of blood total‐ and LDL‐cholesterol, however further study is to confirm the beneficial effects on cardiovascular disease in postmenopausal women.