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Association of adverse antenatal and perinatal events with occurrence of Autism: A Case Control Study
Author(s) -
Al-Farsi Yahya M,
Al-Khaduri Maha M,
Al-Sharbati Marwan M,
Waly Mostafa I,
Al-Farsi Omar A,
Al-Shafaee Mohammed A,
Deth Richard C
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1006.4
Subject(s) - medicine , prospective cohort study , odds ratio , pregnancy , pediatrics , obstetrics , cohort study , gestational diabetes , case control study , autism , logistic regression , retrospective cohort study , nested case control study , cohort , adverse effect , gestation , psychiatry , genetics , biology
Background Early life events, especially during perinatal and neonatal period, have been proposed as important factors in the etiologic pathways of autism. Objectives To evaluate the association between selected antental and perinatal adverse events and autism spectrum disorders (ASD). Methods A retrospective case‐control study has been nested on ongoing prospective cohort study, and it included 102 ASD cases and 102 controls. Results Adjusted odds ratios (OR) were generated from logistic regression models. ASD was found to be associated with social problems during pregnancy (OR = 1.39; 95% CI 1.01, 4.2), serious illness or trauma (OR = 1.5; 95% CI 1.02, 3.2), medication intake during pregnancy (OR = 1.6; 95% CI 0.96, 4.6), and premature delivery (OR = 1.7; 95% CI 1.1, 2.6). No evidence has been obtained for a significant association with gestational diabetes, anemia, and exposure to X‐ray, or caesarian section. Conclusions This study indicates that adverse early life events mightbe associated with increased risk of ASD. Further proof is sought through conduct of an undergoing prospective cohort study.