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High throughput identification of compounds targeting influenza RNA dependent RNA polymerase activity
Author(s) -
Su Ching-Yao,
Wong Chi-Huey
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.1002.3
Subject(s) - rna polymerase , identification (biology) , high throughput screening , computational biology , rna , polymerase , protein subunit , chemistry , biology , virology , biochemistry , gene , botany
We developed an antiinfluenza screening strategy for a HTS campaign against a large compound library. The screening of a large library resulted in the identification of several classes of unique compounds that appear to inhibit influenza at different targets. Two of the identified antiinfluenza compounds inhibit influenza RdRP activities by targeting different subunit proteins. The compound 3061 (FA‐2) interacts with the NP, while the other antiinfluenza inhibitor, 367, prevents PB1 functions. It is conceivable that RdRP could be targeted at many different sites. Optimization of these compounds could result in the development of new antiinfluenza agents. Grant Funding Source : Academia Sinica