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Splanchnic, rather than renal nerves contribute to the maintenance of Dahl salt‐sensitive (SS) hypertension
Author(s) -
Foss Jason,
Fink Gregory D,
Osborn John W
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb611
Subject(s) - splanchnic nerves , splanchnic , denervation , medicine , blood pressure , ganglionectomy , mean arterial pressure , endocrinology , sympathetic nervous system , hemodynamics , heart rate , stimulation , pathology , alternative medicine
The sympathetic nervous system has been implicated in the pathogenesis of salt‐sensitive hypertension; however, the specific sympathetic targets involved remain unclear. The present study tested the hypothesis that splanchnic nerves play a greater role than renal nerves in the maintenance of elevated blood pressure in the Dahl SS rat, a genetic model of salt‐sensitive hypertension. Dahl SS rats were fed a low salt diet (0.1% NaCl) and instrumented with radiotelemeters to measure mean arterial pressure (MAP). After 10 days of recovery and a 4 day baseline period, rats were put on a high salt diet (4% NaCl) for 6 weeks. On average, MAP increased approximately 25 mmHg by the end of the 3 rd week of high salt. At this time the rats were subjected to either celiac ganglionectomy (CGX; n = 4), renal denervation (RDNX; n = 3) or a sham surgery (SHAM; n = 4). Immediately following surgery, MAP transiently dropped in all groups and then slowly increased over the remainder of the protocol. This increase, however, was markedly attenuated in CGX rats. By 3 weeks post surgery, the change in MAP from the day before surgery was significantly less in CGX rats (3.0 ± 2.2 mmHg) than in RDNX (14.8 ± 3.2 mmHg) and SHAM (19.5 ± 1.1 mmHg) rats. These data support the hypothesis that the splanchnic, but not renal, nerves contribute to the maintenance of Dahl SS hypertension. Supported by R01HL076312.