Premium
Attenuated regional vasodilatory effects of gastrointestinal hormones in obesity prone animals: implications for obesity‐related hypertension
Author(s) -
How Jackie May Yen,
Pumpa Talia Jane,
Sartor Daniela Maria
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb607
Subject(s) - medicine , endocrinology , leptin , vasodilation , cholecystokinin , vascular resistance , splanchnic , hormone , mesenteric arteries , obesity , blood pressure , artery , hemodynamics , receptor
Obese animals have reduced renal and splanchnic sympathoinhibitory responses to gastrointestinal hormones that may have implications for increased vascular resistance. Our aim was to determine whether the vasodilatory effects induced by gastric leptin and cholecystokinin (CCK) are also attenuated in obesity. Male Sprague‐Dawley rats were fed a medium high fat diet (MHFD; n =24) or a low fat diet (LFD; n =8) for 13 weeks. Based on weight gain, MHFD rats were stratified into obesity prone (OP; upper tertile; n =8) or obesity resistant (OR; lower tertile; n =8) groups. Baseline arterial pressure (AP) was recorded in isoflurane‐anesthetised rats and Doppler flow probes were attached to the renal and superior mesenteric (SM) arteries for measurement of vascular conductance (VC). CCK was administered intravenously (0.1‐4 μg/kg) and leptin (15 μg/kg) infused close to the coeliac artery. OP rats had elevated AP compared to both LFD and OR rats ( P <0.05 for all). CCK increased renal VC in LFD and OR rats and this response was blunted in OP rats (0.5‐4 μg/kg; P <0.05 for all). Leptin significantly increased renal VC in LFD compared to OP rats ( P <0.05). In the SM artery, CCK increased VC in LFD animals, and this response was attenuated in OP rats (1–2 μg/kg; P <0.05 for all). Reduced vasodilatory effects of gut hormones may contribute to elevated vascular resistance associated with obesity‐related hypertension.