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894G>T polymorphism of endothelial nitric oxide synthase impairs hemodynamic responses to mental stress
Author(s) -
Rocha Natália Galito,
Silva Bruno Moreira,
Neves Fabricia Junqueira,
Medeiros Renata Frauches,
Carvalho Ana Cristina Gouvea,
Sales Allan Robson Kluser,
Toste Fabiane Pereira,
Pereira Felipe Sá,
Barbosa Thales Coelho,
Nóbrega Antonio Claudio Lucas
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb553
Subject(s) - medicine , hemodynamics , mental stress , blood pressure , endocrinology , forearm , cardiology , psychology , surgery
Our aim was to evaluate the effect of the 894G>T polymorphism on the hemodynamic responses to mental stress performed before and after exercise. Subjects without (wild type, WT; n=16) or with (polymorphic type, PT; n=19) the polymorphism underwent a mental stress challenge before and after a bout of maximal dynamic exercise on a treadmill. Blood pressure and forearm blood flow were measured during mental stress. Before exercise, systolic blood pressure (SBP) response during mental stress was higher in the PT group (ΔWT: 8.0±2.0% vs. ΔPT: 12.5±1.8%, P=0.01), while the increase in forearm vascular conductance (FVC) was similar between the groups (ΔWT 90.8±26.4% vs. ΔPT: 86.3±24.1%, P=0.44). After exercise, the SBP at baseline and during mental stress was lower than before exercise in the whole group (P<0.05), but the pressure response during mental stress was still higher in the PT group (ΔWT: 5.8±1.5% vs. ΔPT: 10.2±1.4%, P=0.01). The increase in FVC was inhibited only in the PT group (Δbefore exercise 86.3±24.1% vs. Δafter exercise: 41.5±12.6%, P=0.04). In conclusion, subjects with the 894G>T polymorphism presented higher blood pressure response to mental stress, both before and after exercise along with blunted FVC increase after exercise. These results suggest that the 894G>T polymorphism is associated with altered hemodynamic responses to mental stress with potential clinical implications. Support: CNPq, FAPERJ, FINEP.