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LOW INTENSITY RESISTANCE TRAINING IMPROVES METABOLIC PROFILE OF DIABETIC RATS
Author(s) -
Macedo Fabricio N,
Barreto André Sales,
Mota Marcelo Mendonça,
Santos Soares Ana Paula,
Fontes Milene Tavares,
Silva Tharciano Luiz Teixeira Braga,
Melquiades Neto José Rezende,
Santos Márcio Roberto Viana
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb541
Subject(s) - fructosamine , tbars , endocrinology , medicine , creatinine , diabetes mellitus , chemistry , zoology , lipid peroxidation , biology , oxidative stress
The aim of this study was to evaluate the effects of RT on glucose, lipids, urea, creatinine, PCRhs, fructosamine and blood TBARS, and mass indexes heart, liver and muscle in diabetic rats induced by alloxan (40 mg/kg, iv). For all experiments we used male Wistar rats weighing 200–300g. The animals were divided into 3 groups (n=8 for each group), sedentary control (SC), sedentary diabetic (SD) and trained diabetic (TD) rats. The RT was performed in a squat‐training apparatus using 3x10 repetitions, 3 times a week for 8 weeks After measurement of the maximum weight lifted (1RM) the training load was set at 40% of 1RM and adjusted each 15 days. At the end of the RT protocol or time control, the animals were anesthetized with sodium thiopental (45 mg/kg i.p.) and sample blood and tissues were obtained. The RT was able to reduce blood glucose (from 381 ± 42 to 270 ± 17 mg/dL), plasma TBARS (1.4 ± 0.02 to 0.2 ± 0.05 nmol/ml) and liver mass index (0.0467 ± 0.0036 to 0.0391 ± 0.0034), and to increase HDL (from 16.25 ± 2.25 to 36.6 ± 6.7) and plantar muscle mass index (from 0.00295 ± 0.00026 to 0.00377 ± 0.00005) in relation to the SD. These results demonstrate that the low intensity RT is a useful non‐pharmacological intervention to treatment of metabolic complications from diabetes. Research Support: CAPES, Fapitec‐SE.