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Role of vitamin C on protection against toxic effects of cadmium
Author(s) -
Sopi Skender,
Masurica Feim,
Bozo Seit
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb397
Subject(s) - ascorbic acid , alkaline phosphatase , superoxide dismutase , catalase , lipid peroxidation , chemistry , vitamin c , cadmium , enzyme , alanine aminotransferase , antioxidant , acid phosphatase , vitamin e , medicine , biochemistry , vitamin , endocrinology , biology , food science , organic chemistry
In the present study, an investigation was undertaken to assess the protective efficacy of vitamin C on cadmium (Cd) toxic effects in liver. New Zeland rabbits were divided in four groups and orally was given Cd (2 mg/kg/bw/day) or ascorbic acid (AA), (50 mg/kg/bw/day) alone, and in one group of animals both ascorbic acid and Cd were applied simultaneously in same animals. Control animals received saline. The activity of plasma hepatic marker enzymes, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), superoxide dismutase (SOD) and catalase, as well as membrane lipid peroxidation (LPO) was measured. In Cd treated animals, activity of enzymes and LPO were increased significantly, compared with control animals, however in AA treated group these parameters did not change. Simultaneous treatment of animals with AA and Cd, decreased the enzymes activity and LPO almost at control level. The result of this study, confirm a protective role of vitamin C on Cd‐induced liver damage.