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Apocynin derivatives as potential inhibitors of NADPH oxidase
Author(s) -
Macias Martha Edith,
Martinez Federico,
Padilla Itzia Irene,
Correa Jose,
Rosales Martha Cecilia
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb387
Subject(s) - apocynin , nadph oxidase , nicotinamide adenine dinucleotide phosphate , superoxide , chemistry , oxidase test , pharmacology , biochemistry , enzyme , medicine
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase), is the major source of superoxide anion (O2.‐), wich is a free radical and reacts with Nitric Oxide (NO) decreasing its bioavailability in endothelial cells producing severe cardiovascular diseases such as hypertension. It had been reported that Apocynin inhibit NADPH oxidase, however, has not been used as a therapeutic treatment, due to Apocynin needs to be converts to its dimeric form by Mieloperoxidasa (MPO) and this enzyme has low affinity for Apocynin. Therefore, in this work were synthesized a set of Apocynin ethers with the main to compounds as obtain better NADPH oxidase inhibitor than Apocynin and avoiding the MPO dimerization. The inhibitory activity of the compounds was evaluated by Electron Paramagnetic Resonance (EPR) employed homogenized of aortic tissue contained NADPH oxidase of spontaneously hypertensive (SHR/NHsd) and normotensive (WKY/NHsd) rats.