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Increased oxidative stress in patients undergoing coronary artery bypass surgery predicts a higher coronary risk
Author(s) -
Tejerina Teresa,
GonzalezCorrea JoseAntonio,
Carnero Manuel,
MunozMarin Javier,
De la Cruz JosePedro,
NavarroDorado Jorge,
Ramajo Marta,
Redondo Santiago
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb369
Subject(s) - oxidative stress , medicine , coronary artery disease , cardiology , framingham risk score , artery , superoxide dismutase , bypass grafting , nitrite , surgery , chemistry , disease , organic chemistry , nitrate
We studied multiple oxidative stress related products in patients who underwent coronary artery bypass grafting (CABG). Materials We measured 2 hours before and 24 after CABG the concentration of malondialdehidic acid (MDA), nitrates, and peroxynitrites (prooxidative markers); and reducted glutation and mitochondrial superoxide dismutase (SOD‐Mn) (antioxidative markers). Results 119 patients were included. Statistically significant differences were detected in the plasmatic MDA concentration before (0.148 mM) and after (0.283 mM) surgery (p<0.001). A trend towards higher concentrations of peroxynitrates (p=0.443) and nitrates (p=0.078) was also noted. A trend towards lower levels of reducted glutation and SOD‐Mn was noted (p=0.94 and p=0.070). Hematite MDA and nitrite levels were predictors of greater Framingham/ATP III score (B=32.146 points/mM/ml (IC 95% 24.132–40.16); B=0.326 points/μM/g (IC 95% 0.049–0.604). GSH levels were inversely related to Framingham/ATP III score (B= −0.175 points/μM/g (IC 95%=−0.344‐ −0.005)). Conclusions CABG surgery worsens the oxidative stress profile in patients with coronary disease by increasing oxidation/ antioxidation balance.