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Bowel Morphologic evaluation in Experimental Administration of an Extract Ethanolic of Genipa Americana
Author(s) -
DE SOUZA CAVALCANTI KAREN PENA,
SOUZA IVONE ANTONIA,
Caribe Rebeca Alves,
Silva Elisangela Christianne Barbosa,
Cabrita Antonio Silverio
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb337
Subject(s) - cecum , medicine , rectum , gastroenterology , incidence (geometry) , traditional medicine , physics , optics
Genipa americana L. (Rubiacea), native to northern South America, has a broad distribution in nearly all Brazilian territory, constituting a species with potential for commercial cultivation and use in agroforestry systems. The fruit serves as hair and skin dye, edible food and as folk medicine. This study propose to evaluate whether there are possible bowel lesions caused by ethanolic extract (EE) of fruit from G. americana. Twenty Wistar males rats 8 weeks of age were distributed randomly in 2 groups with 10 animals each. Group I constituted a control group with no manipulation. The group II was submitted to the administration of the 100mg/Kg of EE of G. americana, by gavage, five times at week, during 8 weeks. All the animals were sacrificed after twenty‐eight weeks. The bowel of control had no lesions. The incidence of AC observed in the group II was 1.67 ± 2.5 (2.6%) in the rectum, 50.22 ± 21.32 (78.34%) in the colon and 13.75 ± 4.89 (19.06%) in the cecum. Therefore, there were no neoplasm lesions. In conclusion, the macroscopic evaluation of the bowel revealed aberrant crypts (AC) and there were no neoplasmic lesions in the groups treated with the HE of the G. americana.