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Estrogen receptor‐alpha genotype affects exercise‐related bone mass in young healthy women
Author(s) -
Kondo Hiroyo,
Fujino Hidemi,
Murakami Shinichiro,
Fujita Naoto,
Nagatomo Fumiko,
Ishihara Akihiko
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb303
Subject(s) - medicine , endocrinology , estrogen receptor alpha , peak bone mass , osteoporosis , bone remodeling , heterozygote advantage , bone mineral , estrogen receptor , bone density , estrogen , genotype , biology , genetics , cancer , breast cancer , gene
Osteoporosis is a systemic skeletal disease characterized by low bone mass and/or fragile bone. The estrogen receptor alpha (ESR1) is a good genetic candidate for a prime regulator of bone metabolism. The purpose of this study was to assess the interactive effects of exercise and/or calcium intake and ESR1 polymorphism on bone mass. Eighty healthy young women (20–23 yr) were recruited in this study. Bone mass and body composition were measured. Food frequency and exercise‐related questionnaires were used to estimate calcium intake and exercise intensity. The ESR1 polymorphisms at intron 1(rs2234693 and rs9340799) were genotyped using the TaqMan‐based SNP method. Exercise and milk‐intake were significantly associated with bone mass in the whole subjects. The bone mass in non‐exercised participants with CC homozygote was lower than that in TT homozygote. The bone mass in high‐intensity exercised participants with CC homozygote was higher than that in low‐intensity. The bone mass in high‐intensity exercised participants carrying both CT and AG heterozygotes was significantly higher than that in low‐intensity. These results suggest that exercise attenuates are the increase of peak bone mass in young women carrying both C allele and AG heterozygote in estrogen receptor alpha. This study was supported by Grants for Research and Education from Nagoya Women fs University.