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Differential effect of quercetin and quercetin‐3‐glucoside on the proliferation of cancer cells
Author(s) -
You Hyun Ju,
Ahn Hyung Jin,
Ji Geun Eog
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb301
Subject(s) - quercetin , cancer cell , chemistry , cell growth , cell cycle , cyclin d1 , cancer , cancer research , biochemistry , biology , cell , antioxidant , genetics
While most of flavonoids in plant and food sources exist as glycosidic‐conjugated forms, biological functions of glycones have been less studied than their aglycones. We investigated the differential anti‐proliferative effects of quercetin and its glycone, quercetin‐3‐glucoside (Q3G) on cancer cells. Q3G increased the anti‐proliferative effect of quercetin noticeably in the 7 cancer cell lines. Furthermore, treatment with Q3G induced higher degree of G 1 cell cycle arrest and sub‐G 1 phase of colon cancer cells than quercetin. Q3G also showed more potent activity than quercetin in decreasing the protein levels of cyclin D1, cyclin D3, CDK4, and CDK6, and increasing the mRNA and protein levels of p21 CIP1 in a p53‐independent manner. These results represented the increased anti‐proliferative effect of glucosylated quercetin through the regulation of cell‐cycle related proteins in G 1 arrest. This work was supported by the 21C Frontier Microbial Genomics and Applications Center Program, Ministry of Science and Technology (MG08‐0303‐4‐0), Republic of Korea.