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Protection of Oxidant‐induced astrocytes Injury by a Unique Cruciferous Nutraceutical
Author(s) -
Jia Zhenquan,
Zhu Hong,
Li Yunbo,
Misra Hara P.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb282
Subject(s) - neuroprotection , oxidative stress , chemistry , reactive oxygen species , glutathione , pharmacology , nutraceutical , biochemistry , nad+ kinase , antioxidant , biology , enzyme
The involvement of reactive oxygen species and electrophiles in the pathogenesis of various neurodegenerative disorders has provoked extensive studies on the use of exogenous antioxidative compounds to prevent oxidative neurodegenerative processes with little effects. In this study, we demonstrated that the cruciferous nutraceutical 3H‐1,2‐dithiole‐3‐thione (D3T) at micromolar concentrations (10–100 μM) has the potential to induce the levels of reduced glutathione (GSH) and NAD(P)H:quinone oxidoreductase 1 (NQO1), two crucial cellular defenses against oxidative and electrophilic stress in human astrocytes. In addition, pretreatment with D3T protected cells from oxidative and electrophilic neurocytotoxicity induced by various neurotoxicants including acrolein, 4‐hydroxy‐2‐nonenal (HNE), 6‐hydroxydopamine (6‐OHDA) and 1‐methyl‐4‐phenylpyridinium (MPP+). The results of this study may have important implications for the development of novel neuroprotective strategies against neurodegenerative disorders underlying Parkinson's disease.