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Effect of weekly vs daily zinc supplementation on inflammation and oxidative stress markers in women
Author(s) -
Tejero Maria Elizabeth,
Garza M,
Gaytan A,
Gutiérrez A,
Isoard Fernando,
PerezLizaur Ana,
De Regil Luz Ma
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb274
Subject(s) - tbars , oxidative stress , adiponectin , zinc , medicine , endocrinology , placebo , insulin , chemistry , insulin resistance , lipid peroxidation , alternative medicine , organic chemistry , pathology
Zinc is involved in numerous enzymatic reactions, some of them aimed to control the effects of inflammation and oxidative stress. Participants were healthy adult women, non‐pregnant or breastfeeding, non anemic, who were not consuming vitamin or mineral supplements. They were randomly assigned one of three groups (n=15 per group) to receive 1) placebo, 2) 30 mg of zinc or 3) 90 mg of zinc weekly for 4 weeks. Zinc was given as gluconate. Anthropometry, dietary intake, fasting glucose, insulin, adiponectin, IL‐6, zinc in plasma and erithrocytes, and Tbars were measured pre‐post intervention. Side effects were recorded on a diary card. Differences within and among groups were analyzed by a Student t test and one way ANOVA, respectively. Zinc levels increased significantly in plasma and erythrocytes in the supplemented groups. No differences were observed on glucose, insulin, adiponectin and Tbars levels across the compared groups. A low incidence of side effects such as GI tract discomfort were reported in the supplemented groups.