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PROMOTION OF HAIR REGENERATION BY ARALIA CONTINENTALIS ROOT EXTRACT IN C57BL/6 MICE
Author(s) -
Park Soojin,
Yang KyungAh,
Lee Hyunmin,
Yang Yoonjung,
Kang Sechan
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.lb233
Subject(s) - medicine , minoxidil , traditional medicine , regeneration (biology) , dorsum , pharmacology , dermatology , biology , anatomy , microbiology and biotechnology
Aralia ( Aralia cordata Thunb.) has been documented to possess anti‐inflammation as well as pain relieving effects against rheumatic arthritis and dermatitis in traditional oriental medicine. Among 50 Korean natural herb extracts, aralia continentalis extract (ACE) was screened as candidate for hair regeneration effect in the preliminary animal study. To evaluate the effect of ACE on hair generation in C57BL/6, animals were divided into 4 groups including vehicle control (30% ethanol), positive control (5% minoxidil) and experimental groups (ACE, 1 and 10 mg/ml). And they were topically applied individual treatments on the depilated dorsal skin with an amount of 100 ul everyday for 4 weeks. Hair regeneration was evaluated by photographical and histological observations. ACE groups promoted development of hair follicles approximately 20% more than vehicle group through the stimulation of anagen progression of the hair shaft. Interestingly, hair reconstitution was more effective in the low dose ACE group than the high dose ACE group. In conclusion, our results implicate the enriching potential of ACE for hair regeneration. A further study will present whether the synergistic effect of oral and topical administrations of ACE on hair restoration. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2009‐0067117).